Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-&#954;B activation.

Yu, L; Chen, J F; Shuai, X; Xu, Y; Ding, Y; Zhang, J; Yang, W; Liang, X; Su, D; Yan, C

Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation.

Yu, L; Chen, J F; Shuai, X; Xu, Y; Ding, Y; Zhang, J; Yang, W; Liang, X; Su, D; Yan, C.

Afiliação

Yu L; Department of Pathology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Chen JF; Department of Endocrinology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Shuai X; Department of Pathology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Xu Y; Department of Pathology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Ding Y; Department of Pathology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Zhang J; Department of Laboratory Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Yang W; Department of Laboratory Medicine, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Liang X; The Center of Metabolic Disease Research, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Su D; Department of Pathology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China. sudongming@njmu.edu.cn.
Yan C; Department of Endocrinology, Clinical Medical College of Yangzhou University, Yangzhou, 225001, Jiangsu, China. yancaifeng@126.com.

J Endocrinol Invest ; 39(1): 83-91, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26062521

Assuntos

Artemisininas/farmacologia; Citocinas/farmacologia; Citoproteção/efeitos dos fármacos; Células Secretoras de Insulina/efeitos dos fármacos; NF-kappa B/antagonistas & inibidores; Sirtuína 1/fisiologia; Animais; Apoptose/efeitos dos fármacos; Artesunato; Células Cultivadas; Estudos de Viabilidade; Células Secretoras de Insulina/fisiologia; Masculino; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Artesunate; IL-1ß; NF-κB; Pancreatic beta-cell; SIRT1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / NF-kappa B / Citoproteção / Artemisininas / Células Secretoras de Insulina / Sirtuína 1 Limite: Animals Idioma: En Revista: J Endocrinol Invest Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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