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A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol.
Romek, Katarzyna M; Nun, Pierrick; Remaud, Gérald S; Silvestre, Virginie; Taïwe, Germain Sotoing; Lecerf-Schmidt, Florine; Boumendjel, Ahcène; De Waard, Michel; Robins, Richard J.
Afiliação
  • Romek KM; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, CNRS-University of Nantes Unité Mixte de Recherche 6230, F-44322 Nantes, France; Laboratory for Isotope Effects Studies, Department of Chemistry, Institute of Applied Radiation Che
  • Nun P; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, CNRS-University of Nantes Unité Mixte de Recherche 6230, F-44322 Nantes, France;
  • Remaud GS; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, CNRS-University of Nantes Unité Mixte de Recherche 6230, F-44322 Nantes, France;
  • Silvestre V; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, CNRS-University of Nantes Unité Mixte de Recherche 6230, F-44322 Nantes, France;
  • Taïwe GS; Department of Zoology and Animal Physiology, University of Buea, Buea, Cameroon;
  • Lecerf-Schmidt F; Department of Medicinal Chemistry, University Grenoble Alpes-CNRS Unité Mixte de Recherche 5063, F-38041 Grenoble, France;
  • Boumendjel A; Department of Medicinal Chemistry, University Grenoble Alpes-CNRS Unité Mixte de Recherche 5063, F-38041 Grenoble, France;
  • De Waard M; Grenoble Institute of Neuroscience, Unit Inserm U836, F-38700 La Tronche, France; University Joseph Fourier, F-38041 Grenoble, France.
  • Robins RJ; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, CNRS-University of Nantes Unité Mixte de Recherche 6230, F-44322 Nantes, France; Richard.ROBINS@univ-nantes.fr.
Proc Natl Acad Sci U S A ; 112(27): 8296-301, 2015 Jul 07.
Article em En | MEDLINE | ID: mdl-26106160
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tramadol / Espectroscopia de Ressonância Magnética / Vias Biossintéticas / Marcação por Isótopo Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tramadol / Espectroscopia de Ressonância Magnética / Vias Biossintéticas / Marcação por Isótopo Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article