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Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.
Meulendijks, Didier; Jacobs, Bart A W; Aliev, Abidin; Pluim, Dick; van Werkhoven, Erik; Deenen, Maarten J; Beijnen, Jos H; Cats, Annemieke; Schellens, Jan H M.
Afiliação
  • Meulendijks D; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Jacobs BA; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Aliev A; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Pluim D; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • van Werkhoven E; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Deenen MJ; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Beijnen JH; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Cats A; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.
  • Schellens JH; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Int J Cancer ; 138(1): 245-53, 2016 Jan 01.
Article em En | MEDLINE | ID: mdl-26189437
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Timidilato Sintase / Sequências de Repetição em Tandem / Polimorfismo de Nucleotídeo Único / Alelos / Antimetabólitos Antineoplásicos Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Timidilato Sintase / Sequências de Repetição em Tandem / Polimorfismo de Nucleotídeo Único / Alelos / Antimetabólitos Antineoplásicos Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda