Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor.
BMC Cancer
; 15: 557, 2015 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-26223313
ABSTRACT
BACKGROUND:
The objective of the present population-based analysis was to assess survival patterns in patients with resected and metastatic GIST.METHODS:
Patients with histologically proven GIST were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 through 2011. Survival was determined applying Kaplan-Meier-estimates and multivariable Cox-regression analyses. The impact of size and mitotic count on survival was assessed with a generalized receiver-operating characteristic-analysis.RESULTS:
Overall, 5138 patients were included. Median age was 62 years (range 18-101 years), 47.3% were female, 68.8% Caucasians. GIST location was in the stomach in 58.7% and small bowel in 31.2%. Lymph node and distant metastases were found in 5.1 and 18.0%, respectively. For non-metastatic GIST, three-year overall survival increased from 68.5% (95 % CI 58.8-79.8%) in 1998 to 88.6% (95 % CI 85.3-92.0%) in 2008, cancer-specific survival from 75.3% (95 % CI 66.1-85.9%) in 1998 to 92.2% (95 % CI 89.4-95.1%) in 2008. For metastatic GIST, three-year overall survival increased from 15.0% (95 % CI 5.3-42.6%) in 1998 to 54.7% (95 % CI 44.4-67.3%) in 2008, cancer-specific survival from 15.0% (95 % CI 5.3-42.6%) in 1998 to 61.9% (95 % CI 51.4-74.5%) in 2008 (all PTrend < 0.05).CONCLUSIONS:
This is the first SEER trend analysis assessing outcomes in a large cohort of GIST patients over a 11-year time period. The analysis provides compelling evidence of a statistically significant and clinically relevant increase in overall and cancer-specific survival from 1998 to 2008, both for resected as well as metastatic GIST.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumores do Estroma Gastrointestinal
/
Neoplasias Gastrointestinais
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMC Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Suíça