Comparison of Two High-End Ultrasound Systems for Contrast-Enhanced Ultrasound Quantification of Mural Microvascularity in Crohn's Disease.
Ultraschall Med
; 37(1): 74-81, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26251995
ABSTRACT
PURPOSE:
To verify the reproducibility of contrast-enhanced ultrasound (CEUS) quantification results of two different high-end ultrasound systems and to evaluate the clinical utility of the method in patients with Crohn's disease (CD). MATERIALS ANDMETHODS:
18 patients with histologically confirmed CD (36.8â% women, 63.2â% men; mean age 43.7â±â14.1 years) and wall segments thicker than 5âmm were recruited. CEUS quantification and conventional ultrasound investigation were performed under standardized settings using Toshiba Aplio500 and Siemens Acuson S3000 high-end ultrasound systems. CEUS was performed at a low mechanical index of 0.1 after bolus application of 4.8âml of SonoVue(®) contrast medium. The recorded DICOM clips were quantified using VueBox(®) (version 4.3) calculating 11 quantitative parameters. Subsequently, CEUS quantification and conventional ultrasound results were analyzed.RESULTS:
Correlation of quantitative parameters between the Aplio500 and AcusonS3000 systems for peak enhancement (PE), rise time (RT), wash-in-rate (WiR) and quality of fit (QOF) yielded significance levels of pâ<â0.05 and pâ<â0.0001 for wash-in-wash-out area under the curve (WiWoAUC). Spearman rank test showed moderate levels of correlation for PE, RT, WiR and QOF (râ=â0.5, 0.49, 0.49 and 0.5 respectively), and high correlation for WiWoAUC (râ=â0.89) between the two ultrasound systems.CONCLUSION:
Due to multiple uncontrollable affecting factors, the method of CEUS quantification by VueBox in the intestine cannot be recommended for device-independent multicenter studies. Therefore we suggest to use identical ultrasound systems and probes as well as to establish adequate reference ROIS, like a AIF-ROI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Hexafluoreto de Enxofre
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Doença de Crohn
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Ultrassonografia Doppler em Cores
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Meios de Contraste
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Desenho de Equipamento
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Microvasos
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Íleo
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Mucosa Intestinal
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ultraschall Med
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha