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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Hoyt, Scott B; Petrilli, Whitney; London, Clare; Liang, Gui-Bai; Tata, Jim; Hu, Qingzhong; Yin, Lina; van Koppen, Chris J; Hartmann, Rolf W; Struthers, Mary; Wisniewski, Tom; Ren, Ning; Bopp, Charlene; Sok, Andrea; Cai, Tian-Quan; Stribling, Sloan; Pai, Lee-Yuh; Ma, Xiuying; Metzger, Joe; Verras, Andreas; McMasters, Daniel; Chen, Qing; Tung, Elaine; Tang, Wei; Salituro, Gino; Buist, Nicole; Clemas, Joe; Zhou, Gaochao; Gibson, Jack; Maxwell, Carrie Ann; Lassman, Mike; McLaughlin, Theresa; Castro-Perez, Jose; Szeto, Daphne; Forrest, Gail; Hajdu, Richard; Rosenbach, Mark; Xiong, Yusheng.
Afiliação
  • Hoyt SB; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Petrilli W; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • London C; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Liang GB; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Tata J; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Hu Q; Department of Pharmaceutical and Medicinal Chemistry, Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) , Campus C2-3, D-66123 Saarbrücken, Germany.
  • Yin L; Department of Pharmaceutical and Medicinal Chemistry, Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) , Campus C2-3, D-66123 Saarbrücken, Germany ; ElexoPharm GmbH , Im Stadtwald, D-66123 Saarbrücken, Germany.
  • van Koppen CJ; ElexoPharm GmbH , Im Stadtwald, D-66123 Saarbrücken, Germany.
  • Hartmann RW; Department of Pharmaceutical and Medicinal Chemistry, Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) , Campus C2-3, D-66123 Saarbrücken, Germany.
  • Struthers M; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Wisniewski T; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Ren N; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Bopp C; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Sok A; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Cai TQ; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Stribling S; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Pai LY; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Ma X; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Metzger J; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Verras A; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • McMasters D; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Chen Q; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Tung E; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Tang W; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Salituro G; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Buist N; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Clemas J; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Zhou G; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Gibson J; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Maxwell CA; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Lassman M; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • McLaughlin T; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Castro-Perez J; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Szeto D; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Forrest G; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Hajdu R; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Rosenbach M; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Xiong Y; Merck Research Laboratories , Rahway, New Jersey 07065, United States.
ACS Med Chem Lett ; 6(8): 861-5, 2015 Aug 13.
Article em En | MEDLINE | ID: mdl-26288685
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos