What common biomarkers characterize a triple-negative profile in breast cancer?
Pathol Biol (Paris)
; 63(4-5): 224-9, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26300241
ABSTRACT
Triple-negative breast cancers are not a homogeneous subgroup. There is substantial intra-subgroup diversity in tumor biology, prognosis and treatment sensitivity. Then, these triple-negative phenotype (TNP) groups, having specific features, can be again divided into subclasses based on an added immunohistochemical markers. The challenge in treating TNP breast cancers is that they are not responsive to antiestrogens or trastuzumab secondary to negative receptor status, and as a result have a poor prognosis. Therefore, the presence or absence of supplementary markers could help predict which therapies are best suited for patients based on the pattern that their disease markers show. In this review, we will recapitulate the major supplementary biomarkers related to triple-negative breast cancer, which could give new therapeutic options.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Carcinoma Lobular
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Carcinoma Ductal de Mama
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Neoplasias de Mama Triplo Negativas
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Proteínas de Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Pathol Biol (Paris)
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Tunísia