Vitamin D-Binding Protein in Health and Chronic Kidney Disease.
Semin Dial
; 28(6): 636-44, 2015.
Article
em En
| MEDLINE
| ID: mdl-26332676
ABSTRACT
Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D. Nearly all circulating vitamin D (~85-90%) circulates bound to DBP, with a smaller proportion bound to albumin, leaving <5% circulating freely. DBP may also play roles beyond vitamin D binding, with potential roles in the immune system and elsewhere. Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity. This review focuses on the known roles of DBP in health and kidney disease, and current views on the relevance of DBP polymorphisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Proteína de Ligação a Vitamina D
/
Insuficiência Renal Crônica
Limite:
Humans
Idioma:
En
Revista:
Semin Dial
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2015
Tipo de documento:
Article