Deletion of ARNT/HIF1ß in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.

Pillai, Renjitha; Paglialunga, Sabina; Hoang, Monica; Cousteils, Katelyn; Prentice, Kacey J; Bombardier, Eric; Huang, Mei; Gonzalez, Frank J; Tupling, A Russell; Wheeler, Michael B; Joseph, Jamie W

Pillai, Renjitha; Paglialunga, Sabina; Hoang, Monica; Cousteils, Katelyn; Prentice, Kacey J; Bombardier, Eric; Huang, Mei; Gonzalez, Frank J; Tupling, A Russell; Wheeler, Michael B; Joseph, Jamie W.

Afiliação

Pillai R; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.
Paglialunga S; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.
Hoang M; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.
Cousteils K; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.
Prentice KJ; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Bombardier E; Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada.
Huang M; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.
Gonzalez FJ; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Tupling AR; Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada.
Wheeler MB; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Joseph JW; School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5. j3joseph@uwaterloo.ca.

Diabetologia ; 58(12): 2832-42, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26409461

Assuntos

Translocador Nuclear Receptor Aril Hidrocarboneto/genética; Glucose/metabolismo; Homeostase/genética; Células Secretoras de Insulina/enzimologia; Animais; Translocador Nuclear Receptor Aril Hidrocarboneto/deficiência; Teste de Tolerância a Glucose; Hormônio do Crescimento Humano/metabolismo; Humanos; Insulina/metabolismo; Secreção de Insulina; Potencial da Membrana Mitocondrial; Camundongos; Camundongos Knockout; NADP/metabolismo; Consumo de Oxigênio; Troca Gasosa Pulmonar

Palavras-chave

ARNT/HIF1ß; Insulin release; Metabolism; Pancreatic beta cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Secretoras de Insulina / Translocador Nuclear Receptor Aril Hidrocarboneto / Glucose / Homeostase Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Diabetologia Ano de publicação: 2015 Tipo de documento: Article

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