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Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling.
Neale, Peta A; Ait-Aissa, Selim; Brack, Werner; Creusot, Nicolas; Denison, Michael S; Deutschmann, Björn; Hilscherová, Klára; Hollert, Henner; Krauss, Martin; Novák, Jirí; Schulze, Tobias; Seiler, Thomas-Benjamin; Serra, Helene; Shao, Ying; Escher, Beate I.
Afiliação
  • Neale PA; Smart Water Research Centre, School of Environment, Griffith University , Southport QLD 4222, Australia.
  • Ait-Aissa S; National Research Centre for Environmental Toxicology (Entox), The University of Queensland , Brisbane QLD 4108, Australia.
  • Brack W; Institut National de l'Environnement Industriel et des Risques INERIS, Unité d'Ecotoxicologie , 60550 Verneuil-en-Halatte, France.
  • Creusot N; UFZ - Helmholtz Centre for Environmental Research , 04318 Leipzig, Germany.
  • Denison MS; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University , 52074 Aachen, Germany.
  • Deutschmann B; Institut National de l'Environnement Industriel et des Risques INERIS, Unité d'Ecotoxicologie , 60550 Verneuil-en-Halatte, France.
  • Hilscherová K; Department of Environmental Toxicology, University of California , Davis, California 95616, United States.
  • Hollert H; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University , 52074 Aachen, Germany.
  • Krauss M; Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University , Kamenice 753/5, 62500 Brno, Czech Republic.
  • Novák J; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University , 52074 Aachen, Germany.
  • Schulze T; UFZ - Helmholtz Centre for Environmental Research , 04318 Leipzig, Germany.
  • Seiler TB; Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University , Kamenice 753/5, 62500 Brno, Czech Republic.
  • Serra H; UFZ - Helmholtz Centre for Environmental Research , 04318 Leipzig, Germany.
  • Shao Y; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University , 52074 Aachen, Germany.
  • Escher BI; Institut National de l'Environnement Industriel et des Risques INERIS, Unité d'Ecotoxicologie , 60550 Verneuil-en-Halatte, France.
Environ Sci Technol ; 49(24): 14614-24, 2015 Dec 15.
Article em En | MEDLINE | ID: mdl-26516785
Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect the effects of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidative stress (Nrf2), genotoxicity (p53) and inflammation (NF-κB) and the fish embryo toxicity test were applied along with chemical analysis to water extracts from the Danube River. Mixture-toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays, while five chemicals explained up to 80% of ER activation, and three chemicals explained up to 71% of AhR activation. This study highlights the importance of fingerprinting the effects of detected chemicals.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Ecotoxicologia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Environ Sci Technol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Ecotoxicologia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Environ Sci Technol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália