Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA.

Sampey, Gavin C; Saifuddin, Mohammed; Schwab, Angela; Barclay, Robert; Punya, Shreya; Chung, Myung-Chul; Hakami, Ramin M; Zadeh, Mohammad Asad; Lepene, Benjamin; Klase, Zachary A; El-Hage, Nazira; Young, Mary; Iordanskiy, Sergey; Kashanchi, Fatah

Sampey, Gavin C; Saifuddin, Mohammed; Schwab, Angela; Barclay, Robert; Punya, Shreya; Chung, Myung-Chul; Hakami, Ramin M; Zadeh, Mohammad Asad; Lepene, Benjamin; Klase, Zachary A; El-Hage, Nazira; Young, Mary; Iordanskiy, Sergey; Kashanchi, Fatah.

Afiliação

Sampey GC; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Saifuddin M; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Schwab A; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Barclay R; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Punya S; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Chung MC; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Hakami RM; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Zadeh MA; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110.
Lepene B; Ceres Nanosciences Inc., Manassas, Virginia 20110.
Klase ZA; the Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104.
El-Hage N; the Department of Immunology, Herbert Wertheim College of Medicine, Miami, Florida 33199, and.
Young M; the Department of Medicine, Women's Intra-Agency HIV Study, Georgetown University, Washington, D. C. 20007.
Iordanskiy S; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110, siordans@gmu.edu.
Kashanchi F; From the Laboratory of Molecular Virology, George Mason University, Manassas, Virginia 20110, fkashanc@gmu.edu.

J Biol Chem ; 291(3): 1251-66, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26553869

Assuntos

Fatores Ativadores da Transcrição/metabolismo; Citocinas/metabolismo; Exossomos/metabolismo; HIV-1/imunologia; Leucócitos/metabolismo; MicroRNAs/metabolismo; Transporte Ativo do Núcleo Celular; Animais; Linhagem Celular; Linhagem Celular Transformada; Transformação Celular Viral; Células Cultivadas; Exossomos/imunologia; Exossomos/virologia; Infecções por HIV/sangue; Infecções por HIV/imunologia; Infecções por HIV/virologia; Humanos; Interleucina-6/metabolismo; Leucócitos/imunologia; Leucócitos/virologia; Linfotoxina-alfa/metabolismo; Camundongos Endogâmicos NOD; Camundongos Transgênicos; MicroRNAs/sangue; Receptor 3 Toll-Like/antagonistas & inibidores; Receptor 3 Toll-Like/genética; Receptor 3 Toll-Like/metabolismo; eIF-2 Quinase/antagonistas & inibidores; eIF-2 Quinase/genética; eIF-2 Quinase/metabolismo

Palavras-chave

TAR RNA; cytokinesis; exosome (vesicle); human immunodeficiency virus (HIV); macrophage; protein kinase RNA-activated (PKR); toll-like receptor (TLR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / HIV-1 / MicroRNAs / Fatores Ativadores da Transcrição / Exossomos / Leucócitos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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