HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart.

Lam, Chi Keung; Zhao, Wen; Liu, Guan-Sheng; Cai, Wen-Feng; Gardner, George; Adly, George; Kranias, Evangelia G

Lam, Chi Keung; Zhao, Wen; Liu, Guan-Sheng; Cai, Wen-Feng; Gardner, George; Adly, George; Kranias, Evangelia G.

Afiliação

Lam CK; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Zhao W; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Liu GS; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Cai WF; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Gardner G; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Adly G; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575.
Kranias EG; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575 litsa.kranias@uc.edu.

Proc Natl Acad Sci U S A ; 112(47): E6466-75, 2015 Nov 24.

Article em En | MEDLINE | ID: mdl-26553996

Assuntos

Ciclofilinas/metabolismo; Proteínas de Transporte da Membrana Mitocondrial/metabolismo; Miocárdio/metabolismo; Proteínas/metabolismo; Adenoviridae/metabolismo; Animais; Cálcio/metabolismo; Morte Celular; Peptidil-Prolil Isomerase F; Proteínas de Choque Térmico HSP90/metabolismo; Heterozigoto; Humanos; Técnicas In Vitro; Peptídeos e Proteínas de Sinalização Intracelular; Masculino; Camundongos; Membranas Mitocondriais/metabolismo; Poro de Transição de Permeabilidade Mitocondrial; Miócitos Cardíacos/metabolismo; Estresse Oxidativo; Ligação Proteica; Transporte Proteico; Proteólise; Ratos Sprague-Dawley; Ubiquitinação

Palavras-chave

HAX-1; cyclophilin-D; heat shock protein-90; mitochondrial permeability transition; necrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Ciclofilinas / Proteínas de Transporte da Membrana Mitocondrial / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article

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