GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells <i>ex vivo</i>.

Pedroza-Gonzalez, Alexander; Zhou, Guoying; Singh, Simar Pal; Boor, Patrick Pc; Pan, Qiuwei; Grunhagen, Dirk; de Jonge, Jeroen; Tran, Tc Khe; Verhoef, Cornelis; IJzermans, Jan Nm; Janssen, Harry LA; Biermann, Katharina; Kwekkeboom, Jaap; Sprengers, Dave

GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.

Pedroza-Gonzalez, Alexander; Zhou, Guoying; Singh, Simar Pal; Boor, Patrick Pc; Pan, Qiuwei; Grunhagen, Dirk; de Jonge, Jeroen; Tran, Tc Khe; Verhoef, Cornelis; IJzermans, Jan Nm; Janssen, Harry LA; Biermann, Katharina; Kwekkeboom, Jaap; Sprengers, Dave.

Afiliação

Pedroza-Gonzalez A; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands ; Laboratory of Immunology Research, Medicine; Faculty of Higher Studies Iztacala; National Autonomous University of Mexico; FES-Iztacala, UNAM ; Mexico City, Mexico.
Zhou G; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Singh SP; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Boor PP; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Pan Q; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Grunhagen D; Department of Surgery; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
de Jonge J; Department of Surgery; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Tran TK; Department of Surgery; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Verhoef C; Department of Surgery; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
IJzermans JN; Department of Surgery; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Janssen H; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Biermann K; Department of Pathology; Erasmus MC-University Medical Center ; Rotterdam, The Netherlands.
Kwekkeboom J; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.
Sprengers D; Department of Gastroenterology and Hepatology; Erasmus MC University Medical Center ; Rotterdam, The Netherlands.

Oncoimmunology ; 4(12): e1051297, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26587321

Palavras-chave

cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); glucocorticoid-induced tumor necrosis factor receptor (GITR); hepatocellular carcinoma (HCC); liver metastases from colorectal cancer (LM-CRC); regulatory T cells (Treg)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Oncoimmunology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México

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