Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.
Biophys J
; 109(10): 2003-11, 2015 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-26588560
ABSTRACT
General anesthesia is a relatively safe medical procedure, which for nearly 170 years has allowed life saving surgical interventions in animals and people. However, the molecular mechanism of general anesthesia continues to be a matter of importance and debate. A favored hypothesis proposes that general anesthesia results from direct multisite interactions with multiple and diverse ion channels in the brain. Neurotransmitter-gated ion channels and two-pore K+ channels are key players in the mechanism of anesthesia; however, new studies have also implicated voltage-gated ion channels. Recent biophysical and structural studies of Na+ and K+ channels strongly suggest that halogenated inhalational general anesthetics interact with gates and pore regions of these ion channels to modulate function. Here, we review these studies and provide a perspective to stimulate further advances.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anestésicos Inalatórios
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Canais de Sódio Disparados por Voltagem
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biophys J
Ano de publicação:
2015
Tipo de documento:
Article