[Possible neuropharmacological regulation of chemical carcinogenesis caused by diethylnitrosamine]. / O vozmozhnosti neirofarmakologicheskoi reguliatsii khimicheskogo kantserogeneze, vyzvannogo diétilnitrozaminom.
Farmakol Toksikol
; 41(3): 338-42, 1978.
Article
em Ru
| MEDLINE
| ID: mdl-26598
ABSTRACT
The effect of a number of neurotropic drugs on diethylnitrosoamine (DENA)-induced chemical carcinogenesis was studied by applying pharmacological, morphological and biochemical techniques. Atropine stimulated significantly the rat liver and esophagus carcinogenesis, whereas the alpha-adrenoblocking agent, a pyrrhoxane analogue, and, particularly, proserine inhibited these processes. All animals treated with DENA demonstrated a significant increase of liver mitochondrial monoaminoxidase activity. These findings as well as the evidence of a stimulating effect of exogenous norepinephrine on carcionogenesis, together with the literature sources on carcinogenic and modifying carcinogenesis action of neurotropics allow the authors to formulate a concet of the trigger role played by catecholamines in the DENA-induced cell transformation and carcinogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dietilnitrosamina
/
Neoplasias Experimentais
/
Nitrosaminas
Limite:
Animals
Idioma:
Ru
Revista:
Farmakol Toksikol
Ano de publicação:
1978
Tipo de documento:
Article