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HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Ombrello, Michael J; Remmers, Elaine F; Tachmazidou, Ioanna; Grom, Alexei; Foell, Dirk; Haas, Johannes-Peter; Martini, Alberto; Gattorno, Marco; Özen, Seza; Prahalad, Sampath; Zeft, Andrew S; Bohnsack, John F; Mellins, Elizabeth D; Ilowite, Norman T; Russo, Ricardo; Len, Claudio; Hilario, Maria Odete E; Oliveira, Sheila; Yeung, Rae S M; Rosenberg, Alan; Wedderburn, Lucy R; Anton, Jordi; Schwarz, Tobias; Hinks, Anne; Bilginer, Yelda; Park, Jane; Cobb, Joanna; Satorius, Colleen L; Han, Buhm; Baskin, Elizabeth; Signa, Sara; Duerr, Richard H; Achkar, J P; Kamboh, M Ilyas; Kaufman, Kenneth M; Kottyan, Leah C; Pinto, Dalila; Scherer, Stephen W; Alarcón-Riquelme, Marta E; Docampo, Elisa; Estivill, Xavier; Gül, Ahmet; de Bakker, Paul I W; Raychaudhuri, Soumya; Langefeld, Carl D; Thompson, Susan; Zeggini, Eleftheria; Thomson, Wendy; Kastner, Daniel L; Woo, Patricia.
Afiliação
  • Ombrello MJ; Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; ombrellomj@mail.nih.gov kastnerd@mail.nih.gov.
  • Remmers EF; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;
  • Tachmazidou I; Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;
  • Grom A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
  • Foell D; Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster, Germany;
  • Haas JP; German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany;
  • Martini A; Department of Pediatrics, University of Genova, 16145 Genoa, Italy; Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;
  • Gattorno M; Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;
  • Özen S; Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;
  • Prahalad S; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;
  • Zeft AS; Department of Pediatrics, Cleveland Clinic, Cleveland, OH 44195;
  • Bohnsack JF; Department of Pediatrics, University of Utah, Salt Lake City, UT 84113;
  • Mellins ED; Department of Pediatrics, Stanford University, Stanford, CA 94305;
  • Ilowite NT; Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, NY 10461;
  • Russo R; Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires, Argentina;
  • Len C; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;
  • Hilario MO; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;
  • Oliveira S; Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil;
  • Yeung RS; Department of Pediatrics, University of Toronto, Toronto, Canada M5S 1A8; Department of Immunology, University of Toronto, Toronto, Canada M5S 1A8; Institute of Medical Science, University of Toronto, Toronto, Canada M5S 1A8;
  • Rosenberg A; Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada S7N 0W8;
  • Wedderburn LR; Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom; Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;
  • Anton J; Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona, Spain;
  • Schwarz T; Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg, Germany;
  • Hinks A; Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;
  • Bilginer Y; Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;
  • Park J; Department of Pediatrics, Stanford University, Stanford, CA 94305;
  • Cobb J; Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom; National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation
  • Satorius CL; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;
  • Han B; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142; Division of Immunology, Allergy, and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Department of Convergence Medicine, University of Ulsan College of Medicine, As
  • Baskin E; Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Signa S; Department of Pediatrics, University of Genova, 16145 Genoa, Italy;
  • Duerr RH; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261;
  • Achkar JP; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195; Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195;
  • Kamboh MI; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Kaufman KM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
  • Kottyan LC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
  • Pinto D; Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, NY 10029;
  • Scherer SW; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada;
  • Alarcón-Riquelme ME; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016, Spain;
  • Docampo E; Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège, Belgium; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;
  • Estivill X; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;
  • Gül A; Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey;
  • de Bakker PI; Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands; Department of Medical Genetics, Center for Molecular Medicine, University Medica
  • Raychaudhuri S; Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142; Division of Immunology, Allergy, and Rheumatolog
  • Langefeld CD; Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27106.
  • Thompson S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
  • Zeggini E; Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;
  • Thomson W; Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom; National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation
  • Kastner DL; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; ombrellomj@mail.nih.gov kastnerd@mail.nih.gov.
  • Woo P; Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;
Proc Natl Acad Sci U S A ; 112(52): 15970-5, 2015 Dec 29.
Article em En | MEDLINE | ID: mdl-26598658
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Juvenil / Antígenos de Histocompatibilidade Classe II / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Cadeias HLA-DRB1 Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Child / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Juvenil / Antígenos de Histocompatibilidade Classe II / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Cadeias HLA-DRB1 Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Child / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article