Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan; Jin, Chuan; Laaniste, Liisi; El Hassan, Tamador Elsir Abu; Ohlin, K Elisabet; Yu, Di; Olofsson, Tommie; Olsson, Anna-Karin; Pontén, Fredrik; Magnusson, Peetra U; Nilsson, Karin Forsberg; Essand, Magnus; Smits, Anja; Dieterich, Lothar C; Dimberg, Anna

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan; Jin, Chuan; Laaniste, Liisi; El Hassan, Tamador Elsir Abu; Ohlin, K Elisabet; Yu, Di; Olofsson, Tommie; Olsson, Anna-Karin; Pontén, Fredrik; Magnusson, Peetra U; Nilsson, Karin Forsberg; Essand, Magnus; Smits, Anja; Dieterich, Lothar C; Dimberg, Anna.

Afiliação

Zhang L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Kundu S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Feenstra T; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Li X; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Jin C; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Laaniste L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
El Hassan TE; Department of Neuroscience, Neurology, Uppsala University, 751 85 Uppsala, Sweden.
Ohlin KE; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Yu D; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Olofsson T; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Olsson AK; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center, Box 582, SE-75123 Uppsala, Sweden.
Pontén F; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Magnusson PU; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Nilsson KF; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Essand M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Smits A; Department of Neuroscience, Neurology, Uppsala University, 751 85 Uppsala, Sweden.
Dieterich LC; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden.
Dimberg A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185 Uppsala, Sweden. anna.dimberg@igp.uu.se.

Sci Signal ; 8(406): ra125, 2015 Dec 08.

Article em En | MEDLINE | ID: mdl-26645582

Assuntos

Astrocitoma/metabolismo; Astrocitoma/mortalidade; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/mortalidade; Proteínas de Transporte/metabolismo; Citocinas/metabolismo; Proteínas de Neoplasias/metabolismo; Neovascularização Patológica/metabolismo; Neovascularização Patológica/mortalidade; Quinase do Linfoma Anaplásico; Animais; Astrocitoma/genética; Astrocitoma/patologia; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patologia; Proteínas de Transporte/genética; Linhagem Celular Tumoral; Citocinas/genética; Intervalo Livre de Doença; Feminino; Humanos; Masculino; Camundongos; Proteínas de Neoplasias/genética; Neovascularização Patológica/genética; Neovascularização Patológica/patologia; Receptores Proteína Tirosina Quinases/genética; Receptores Proteína Tirosina Quinases/metabolismo; Taxa de Sobrevida; Fator A de Crescimento do Endotélio Vascular/genética; Fator A de Crescimento do Endotélio Vascular/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrocitoma / Neoplasias Encefálicas / Proteínas de Transporte / Citocinas / Proteínas de Neoplasias / Neovascularização Patológica Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suécia

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