Controlled study of haloperidol, pimozide and placebo for the treatment of Gilles de la Tourette's syndrome.
Arch Gen Psychiatry
; 46(8): 722-30, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2665687
ABSTRACT
The results of this controlled study of the treatment of 57 patients with Gilles de la Tourette's syndrome suggested that both haloperidol and pimozide were more effective than placebo, but that haloperidol was slightly more effective than pimozide. Adverse effects occurred more frequently with haloperidol vs placebo than with pimozide vs placebo, but the frequency was not significantly different for haloperidol compared with pimozide. Clinically significant cardiac effects did not occur at a maximum dosage of 0.3 mg/kg or 20 mg/d for pimozide and 10 mg/d for haloperidol. However, the QTc interval was prolonged during pimozide treatment compared with that during haloperidol treatment, although the values for both medications were not in an abnormal range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pimozida
/
Síndrome de Tourette
/
Haloperidol
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Gen Psychiatry
Ano de publicação:
1989
Tipo de documento:
Article