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A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products.
Lloyd, Matthew G; D'Acunto, Mariantonietta; Taylor, Richard J K; Unsworth, William P.
Afiliação
  • Lloyd MG; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
  • D'Acunto M; University of Salerno, Department of Chemistry and Biology, Via Giovanni Paolo II, 132, Salerno, 84084 Fisciano, Italy.
  • Taylor RJ; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
  • Unsworth WP; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
Org Biomol Chem ; 14(5): 1641-5, 2016 Feb 07.
Article em En | MEDLINE | ID: mdl-26695888
ABSTRACT
A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / 4-Butirolactona Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / 4-Butirolactona Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article