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Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
Adams, Mark; Kobayashi, Toshitake; Lawson, J David; Saitoh, Morihisa; Shimokawa, Kenichiro; Bigi, Simone V; Hixon, Mark S; Smith, Christopher R; Tatamiya, Takayuki; Goto, Masayuki; Russo, Joseph; Grimshaw, Charles E; Swann, Steven.
Afiliação
  • Adams M; Medicinal Chemistry, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Kobayashi T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Lawson JD; Computational Sciences and Crystallography, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Saitoh M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Shimokawa K; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Bigi SV; Medicinal Chemistry, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Hixon MS; Global DMPK, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Smith CR; Medicinal Chemistry, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Tatamiya T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Goto M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Russo J; CNS & Novel Target ID, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Grimshaw CE; Computational Sciences and Crystallography, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Swann S; Medicinal Chemistry, Takeda California Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
Bioorg Med Chem Lett ; 26(3): 1086-1089, 2016 Feb 01.
Article em En | MEDLINE | ID: mdl-26704264
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / MAP Quinase Quinase 3 / MAP Quinase Quinase 6 / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / MAP Quinase Quinase 3 / MAP Quinase Quinase 6 / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos