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Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome.
Elouej, Sahar; Belfki-Benali, Hanen; Nagara, Majdi; Lasram, Khaled; Attaoua, Redha; Sallem, Om Kalthoum; Kamoun, Ines; Chargui, Mariem; Romdhane, Lilia; Jamoussi, Henda; Turki, Zinet; Abid, Abdelmajid; Ben Slama, Claude; Bahri, Sonia; Abdelhak, Sonia; Grigorescu, Florin; Ben Romdhane, Habiba; Kefi, Rym.
Afiliação
  • Elouej S; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Belfki-Benali H; 2 Faculté des Sciences de Tunis, Université de Tunis El Manar , El Manar I Tunis, Tunisia .
  • Nagara M; 3 Cardiovascular Epidemiology and Prevention Research Laboratory, Faculty of Medicine , Tunis, Tunisia .
  • Lasram K; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Attaoua R; 2 Faculté des Sciences de Tunis, Université de Tunis El Manar , El Manar I Tunis, Tunisia .
  • Sallem OK; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Kamoun I; 2 Faculté des Sciences de Tunis, Université de Tunis El Manar , El Manar I Tunis, Tunisia .
  • Chargui M; 4 Molecular Endocrinology Laboratory, IURC , Montpellier, France .
  • Romdhane L; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Jamoussi H; 5 Department of External Consultation, National Institute of Nutrition and Food Technology , Tunis, Tunisia .
  • Turki Z; 6 Department of Endocrinology and Metabolic Diseases, National Institute of Nutrition , Tunis, Tunisia .
  • Abid A; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Ben Slama C; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Bahri S; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Abdelhak S; 5 Department of External Consultation, National Institute of Nutrition and Food Technology , Tunis, Tunisia .
  • Grigorescu F; 6 Department of Endocrinology and Metabolic Diseases, National Institute of Nutrition , Tunis, Tunisia .
  • Ben Romdhane H; 1 Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis , Tunis, Tunisia .
  • Kefi R; 5 Department of External Consultation, National Institute of Nutrition and Food Technology , Tunis, Tunisia .
Metab Syndr Relat Disord ; 14(2): 121-8, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26741700
ABSTRACT

BACKGROUND:

Variants in the fat mass and obesity-associated (FTO) gene are associated with obesity and type 2 diabetes mellitus. AIM OF THE STUDY This study aims to assess the association of the rs9939609 variant and haplotypes in FTO gene with metabolic syndrome (MetS) components in a Tunisian population sample.

METHODS:

A total of 685 Tunisian subjects were genotyped for the rs9939609T>A using TaqMan allelic discrimination assay. Two variants rs1421085T>C and rs8057044A>G already genotyped in a previous study were used to test haplotype association of the FTO gene.

RESULTS:

Genotype distribution of the variant rs9939609 was different between MetS and controls (P = 0.017). Individuals carrying TA genotypes had a significantly increased risk independently of body mass index or age (P = 0.009). The variant rs9939609 was also associated with impaired fasting glucose (IFG) (P = 0.002). Among the eight haplotypes in the population, the haplotype GCA was significantly associated with a higher risk of developing the MetS, higher systolic blood pressure, and higher levels of fasting glucose and triglycerides (TGs) in the total sample and females, separately. Separate analysis by gender revealed a protective haplotype TGT among women (P = 0.023).

CONCLUSIONS:

FTO haplotypes have a strong influence on blood pressures and TG and IFG levels. These findings provide evidence that FTO gene may play a critical role in leading to MetS in Tunisian population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Polimorfismo de Nucleotídeo Único / Síndrome Metabólica / Dioxigenase FTO Dependente de alfa-Cetoglutarato Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Metab Syndr Relat Disord Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Tunísia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Polimorfismo de Nucleotídeo Único / Síndrome Metabólica / Dioxigenase FTO Dependente de alfa-Cetoglutarato Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Metab Syndr Relat Disord Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Tunísia