Aqueous extract from Aconitum carmichaelii Debeaux reduces liver injury in rats via regulation of HMGB1/TLR4/NF-&#922;B/caspase-3 and PCNA signaling pathways.

Luo, Jian-Xing; Zhang, Yang; Hu, Xiao-Yu; Chen, Guo; Liu, Xi-Yun; Nie, Hong-Ming; Liu, Jing-Li; Wen, Da-Chao

Aqueous extract from Aconitum carmichaelii Debeaux reduces liver injury in rats via regulation of HMGB1/TLR4/NF-ΚB/caspase-3 and PCNA signaling pathways.

Luo, Jian-Xing; Zhang, Yang; Hu, Xiao-Yu; Chen, Guo; Liu, Xi-Yun; Nie, Hong-Ming; Liu, Jing-Li; Wen, Da-Chao.

Afiliação

Luo JX; Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiao Road, Chengdu 610072, Sichuan, China. Electronic address: 863095714@qq.com.
Zhang Y; Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiao Road, Chengdu 610072, Sichuan, China. Electronic address: 416736357@qq.com.
Hu XY; Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiao Road, Chengdu 610072, Sichuan, China. Electronic address: xiaoyuhu@aliyun.com.
Chen G; Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiao Road, Chengdu 610072, Sichuan, China. Electronic address: chenguo1978@sina.com.
Liu XY; Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China. Electronic address: 84613791@qq.com.
Nie HM; Department of Hepatology Disease, Shanghai Shuguang Hospital, Shanghai University of T.C.M., Shanghai 201203, China. Electronic address: beining0630@126.com.
Liu JL; Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China. Electronic address: 254979859@qq.com.
Wen DC; Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China. Electronic address: 991271163@qq.com.

J Ethnopharmacol ; 183: 187-192, 2016 May 13.

Article em En | MEDLINE | ID: mdl-26806574

Assuntos

Aconitum/química; Caspase 3/metabolismo; Proteína HMGB1/metabolismo; Hepatopatias/tratamento farmacológico; NF-kappa B/metabolismo; Antígeno Nuclear de Célula em Proliferação/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Cisteína/metabolismo; Combinação de Medicamentos; Galactosamina/efeitos adversos; Glicina/metabolismo; Ácido Glicirretínico/análogos & derivados; Ácido Glicirretínico/metabolismo; Fígado/efeitos dos fármacos; Fígado/metabolismo; Hepatopatias/metabolismo; Masculino; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Ratos; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Acute liver failure; Apoptosis; Inflammation; RT-PCRs; Regeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Antígeno Nuclear de Célula em Proliferação / Proteína HMGB1 / Aconitum / Receptor 4 Toll-Like / Caspase 3 / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2016 Tipo de documento: Article

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