Mammalian Autophagy: How Does It Work?
Annu Rev Biochem
; 85: 685-713, 2016 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-26865532
ABSTRACT
Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates include organelles such as mitochondria, aggregate-prone proteins that cause neurodegeneration and various pathogens. Thus, this pathway appears to be relevant to the pathogenesis of diverse diseases, and its modulation may have therapeutic value. Here, we focus on the cell and molecular biology of mammalian autophagy and review the key proteins that regulate the process by discussing their roles and how these may be modulated by posttranslational modifications. We consider the membrane-trafficking events that impact autophagy and the questions relating to the sources of autophagosome membrane(s). Finally, we discuss data from structural studies and some of the insights these have provided.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Processamento de Proteína Pós-Traducional
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Proteínas rab de Ligação ao GTP
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Proteínas SNARE
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Classe III de Fosfatidilinositol 3-Quinases
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Proteínas Relacionadas à Autofagia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2016
Tipo de documento:
Article