Your browser doesn't support javascript.
loading
Economic evaluation of vaccines in Canada: A systematic review.
Chit, Ayman; Lee, Jason K H; Shim, Minsup; Nguyen, Van Hai; Grootendorst, Paul; Wu, Jianhong; Van Exan, Robert; Langley, Joanne M.
Afiliação
  • Chit A; a Sanofi Pasteur , Toronto , Ontario , Canada.
  • Lee JK; b Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto , Ontario , Canada.
  • Shim M; a Sanofi Pasteur , Toronto , Ontario , Canada.
  • Nguyen VH; b Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto , Ontario , Canada.
  • Grootendorst P; b Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto , Ontario , Canada.
  • Wu J; c Health Services and Systems Research Program, Duke-NUS Graduate Medical School Singapore , Singapore.
  • Van Exan R; b Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto , Ontario , Canada.
  • Langley JM; d Department of Economics , McMaster University , Hamilton , Ontario , Canada.
Hum Vaccin Immunother ; 12(5): 1257-64, 2016 05 03.
Article em En | MEDLINE | ID: mdl-26890128
ABSTRACT

BACKGROUND:

Economic evaluations should form part of the basis for public health decision making on new vaccine programs. While Canada's national immunization advisory committee does not systematically include economic evaluations in immunization decision making, there is increasing interest in adopting them. We therefore sought to examine the extent and quality of economic evaluations of vaccines in Canada.

OBJECTIVE:

We conducted a systematic review of economic evaluations of vaccines in Canada to determine and summarize comprehensiveness across jurisdictions, studied vaccines, funding sources, study designs, research quality, and changes over time.

METHODS:

Searches in multiple databases were conducted using the terms "vaccine," "economics" and "Canada." Descriptive data from eligible manuscripts was abstracted and three authors independently evaluated manuscript quality using a 7-point Likert-type scale scoring tool based on criteria from the International Society for Pharmacoeconomics and Outcomes Research (ISPOR).

RESULTS:

42/175 articles met the search criteria. Of these, Canada-wide studies were most common (25/42), while provincial studies largely focused on the three populous provinces of Ontario, Quebec and British Columbia. The most common funding source was industry (17/42), followed by government (7/42). 38 studies used mathematical models estimating expected economic benefit while 4 studies examined post-hoc data on established programs. Studies covered 10 diseases, with 28/42 addressing pediatric vaccines. Many studies considered cost-utility (22/42) and the majority of these studies reported favorable economic results (16/22). The mean quality score was 5.9/7 and was consistent over publication date, funding sources, and disease areas.

CONCLUSIONS:

We observed diverse approaches to evaluate vaccine economics in Canada. Given the increased complexity of economic studies evaluating vaccines and the impact of results on public health practice, Canada needs improved, transparent and consistent processes to review and assess the findings of the economic evaluations of vaccines.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Vacinação / Programas de Imunização Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Hum Vaccin Immunother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Vacinação / Programas de Imunização Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Hum Vaccin Immunother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá