Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread.

Shibata, T; Uchida, H; Shiroyama, T; Okubo, Y; Suzuki, T; Ikeda, H; Yamaguchi, M; Miyagawa, Y; Fukuhara, T; Cohen, J B; Glorioso, J C; Watabe, T; Hamada, H; Tahara, H

Shibata, T; Uchida, H; Shiroyama, T; Okubo, Y; Suzuki, T; Ikeda, H; Yamaguchi, M; Miyagawa, Y; Fukuhara, T; Cohen, J B; Glorioso, J C; Watabe, T; Hamada, H; Tahara, H.

Afiliação

Shibata T; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Uchida H; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Shiroyama T; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Okubo Y; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Suzuki T; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ikeda H; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Yamaguchi M; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Miyagawa Y; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Fukuhara T; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Cohen JB; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Glorioso JC; Division of Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Watabe T; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Hamada H; Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Tahara H; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Gene Ther ; 23(6): 479-88, 2016 06.

Article em En | MEDLINE | ID: mdl-26905369

Assuntos

Molécula de Adesão da Célula Epitelial/genética; Vetores Genéticos/genética; Herpesvirus Humano 1/genética; Neoplasias/terapia; Neoplasias/virologia; Terapia Viral Oncolítica/métodos; Animais; Células CHO; Moléculas de Adesão Celular/genética; Moléculas de Adesão Celular/metabolismo; Linhagem Celular Tumoral; Chlorocebus aethiops/imunologia; Cricetulus; Molécula de Adesão da Célula Epitelial/imunologia; Feminino; Vetores Genéticos/metabolismo; Células Hep G2; Herpesvirus Humano 1/metabolismo; Humanos; Camundongos; Nectinas; Distribuição Aleatória; Receptores Virais/metabolismo; Anticorpos de Cadeia Única/genética; Anticorpos de Cadeia Única/imunologia; Transfecção/métodos; Células Vero; Proteínas do Envelope Viral/genética; Proteínas do Envelope Viral/metabolismo; Internalização do Vírus; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herpesvirus Humano 1 / Terapia Viral Oncolítica / Molécula de Adesão da Célula Epitelial / Vetores Genéticos / Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Gene Ther Assunto da revista: GENETICA MEDICA / TERAPEUTICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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