Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab.

Yonezawa, Atsushi; Chester, Cariad; Rajasekaran, Narendiran; Kohrt, Holbrook E

Yonezawa, Atsushi; Chester, Cariad; Rajasekaran, Narendiran; Kohrt, Holbrook E.

Afiliação

Yonezawa A; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA; Department of Clinical Pharmacology & Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan.
Chester C; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Rajasekaran N; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA.
Kohrt HE; Division of Oncology, Department of Medicine, Stanford University, CCSR Building, Room 1110, Stanford, CA 94305, USA. kohrt@stanford.edu.

Chin Clin Oncol ; 5(1): 5, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26932429

Assuntos

Anticorpos Monoclonais/uso terapêutico; Citotoxicidade Celular Dependente de Anticorpos/imunologia; Sistema Imunitário/imunologia; Imunoterapia; Neoplasias/terapia; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia; Animais; Citotoxicidade Celular Dependente de Anticorpos/efeitos dos fármacos; Ensaios Clínicos como Assunto; Humanos; Sistema Imunitário/efeitos dos fármacos; Neoplasias/imunologia; Prognóstico

Palavras-chave

CD137 is a costimulatory receptor that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 is expressed on T cell, activated NK cells and other immune cells. We recently showed that an agonistic anti-CD137 mAb activates NK cells, resul; Efficacy of anti-CD137 mAb was examined by in vitro and in vivo experiments. Clinical trials of anti-CD137 mAb are also on-going.; Monoclonal antibodies are an invaluable therapeutic class when it comes to cancer therapy. One of the primary mechanisms of anti-tumor activity of monoclonal antibodies is antibody dependent cell-mediated cytotoxicity (ADCC) mediated by natural killer (NK; We discuss some of the promising strategies that could potentially enhance ADCC with anti-CD137 mAbs.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Sistema Imunitário / Imunoterapia / Anticorpos Monoclonais / Citotoxicidade Celular Dependente de Anticorpos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Chin Clin Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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