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TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Lee, Sang Ho; Wang, Hao; Labroli, Marc; Koseoglu, Sandra; Zuck, Paul; Mayhood, Todd; Gill, Charles; Mann, Paul; Sher, Xinwei; Ha, Sookhee; Yang, Shu-Wei; Mandal, Mihir; Yang, Christine; Liang, Lianzhu; Tan, Zheng; Tawa, Paul; Hou, Yan; Kuvelkar, Reshma; DeVito, Kristine; Wen, Xiujuan; Xiao, Jing; Batchlett, Michelle; Balibar, Carl J; Liu, Jenny; Xiao, Jianying; Murgolo, Nicholas; Garlisi, Charles G; Sheth, Payal R; Flattery, Amy; Su, Jing; Tan, Christopher; Roemer, Terry.
Afiliação
  • Lee SH; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Wang H; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Labroli M; Merck Research Laboratories, West Point, PA 19486, USA.
  • Koseoglu S; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Zuck P; Merck Research Laboratories, West Point, PA 19486, USA.
  • Mayhood T; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Gill C; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Mann P; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Sher X; Merck Research Laboratories, Boston, MA 02115, USA.
  • Ha S; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Yang SW; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Mandal M; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Yang C; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Liang L; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Tan Z; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Tawa P; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Hou Y; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Kuvelkar R; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • DeVito K; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Wen X; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Xiao J; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Batchlett M; Merck Research Laboratories, West Point, PA 19486, USA.
  • Balibar CJ; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Liu J; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Xiao J; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Murgolo N; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Garlisi CG; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Sheth PR; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Flattery A; Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Su J; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com.
  • Tan C; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com.
  • Roemer T; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com.
Sci Transl Med ; 8(329): 329ra32, 2016 Mar 09.
Article em En | MEDLINE | ID: mdl-26962156
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Teicoicos / Proteínas de Bactérias / Parede Celular / Beta-Lactamas / Vias Biossintéticas / Staphylococcus aureus Resistente à Meticilina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Teicoicos / Proteínas de Bactérias / Parede Celular / Beta-Lactamas / Vias Biossintéticas / Staphylococcus aureus Resistente à Meticilina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos