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Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.
Gallo, Valentina; Vanacore, Nicola; Bueno-de-Mesquita, H Bas; Vermeulen, Roel; Brayne, Carol; Pearce, Neil; Wark, Petra A; Ward, Heather A; Ferrari, Pietro; Jenab, Mazda; Andersen, Peter M; Wennberg, Patrik; Wareham, Nicholas; Katzke, Verena; Kaaks, Rudolf; Weiderpass, Elisabete; Peeters, Petra H; Mattiello, Amalia; Pala, Valeria; Barricante, Aurelio; Chirlaque, Maria-Dolores; Travier, Noémie; Travis, Ruth C; Sanchez, Maria-Jose; Pessah-Rasmussen, Hélène; Petersson, Jesper; Tjønneland, Anne; Tumino, Rosario; Quiros, Jose Ramon; Trichopoulou, Antonia; Kyrozis, Andreas; Oikonomidou, Despoina; Masala, Giovanna; Sacerdote, Carlotta; Arriola, Larraitz; Boeing, Heiner; Vigl, Matthaeus; Claver-Chapelon, Francoise; Middleton, Lefkos; Riboli, Elio; Vineis, Paolo.
Afiliação
  • Gallo V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus - Norfolk Place, W2 1PG, London, UK. v.gallo@imperial.ac.uk.
  • Vanacore N; Barts and the London School of Medicine, Centre for Primary Care and Public Health, Queen Mary, University of London, London, UK. v.gallo@imperial.ac.uk.
  • Bueno-de-Mesquita HB; Italian National Institute of Health, Rome, Italy.
  • Vermeulen R; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus - Norfolk Place, W2 1PG, London, UK.
  • Brayne C; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Pearce N; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
  • Wark PA; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
  • Ward HA; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Ferrari P; Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Jenab M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus - Norfolk Place, W2 1PG, London, UK.
  • Andersen PM; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus - Norfolk Place, W2 1PG, London, UK.
  • Wennberg P; International Agency for Research on Cancer (IARC), Lyon, France.
  • Wareham N; International Agency for Research on Cancer (IARC), Lyon, France.
  • Katzke V; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
  • Kaaks R; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
  • Weiderpass E; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Peeters PH; Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  • Mattiello A; Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  • Pala V; Department of Community Medicine, Faculty of Health Sciences, The Artic University of Norway, Tromsö, Norway.
  • Barricante A; Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
  • Chirlaque MD; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Travier N; Folkhälsan Research Center, University of Helsinki, Helsinki, Finland.
  • Travis RC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus - Norfolk Place, W2 1PG, London, UK.
  • Sanchez MJ; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Pessah-Rasmussen H; Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
  • Petersson J; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Tjønneland A; Navarre Public Health Institute, Pamplona, Spain.
  • Tumino R; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
  • Quiros JR; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
  • Trichopoulou A; Epidemiology Department, Murcia Regional Health Council, Murcia, Spain.
  • Kyrozis A; Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
  • Oikonomidou D; Cancer Epidemiological Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Masala G; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
  • Sacerdote C; Andalusian School of Public Health, Granada, Spain.
  • Arriola L; Department of Neurology, Skåne University Hospital, Lund University, Malmö, Sweden.
  • Boeing H; Department of Neurology, Skåne University Hospital, Lund University, Malmö, Sweden.
  • Vigl M; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Claver-Chapelon F; Ragusa Cancer Registry, Azienda Ospedaliera "Civile MP Arezzo", Ragusa, Italy.
  • Middleton L; Public Health Directorate, Asturias, Oviedo, Spain.
  • Riboli E; Hellenic Health Foundation, Athens, Greece.
  • Vineis P; Hellenic Health Foundation, Athens, Greece.
Eur J Epidemiol ; 31(3): 255-66, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26968841
Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33% less likely to die from ALS compared to those inactive: HR = 0.67 (95% CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica / Atividade Motora Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica / Atividade Motora Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2016 Tipo de documento: Article