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Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
Kutilek, Victoria D; Andrews, Christine L; Richards, Matthew P; Xu, Zangwei; Sun, Tianxiao; Chen, Yiping; Hashke, Andrew; Smotrov, Nadya; Fernandez, Rafael; Nickbarg, Elliott B; Chamberlin, Chad; Sauvagnat, Berengere; Curran, Patrick J; Boinay, Ryan; Saradjian, Peter; Allen, Samantha J; Byrne, Noel; Elsen, Nathaniel L; Ford, Rachael E; Hall, Dawn L; Kornienko, Maria; Rickert, Keith W; Sharma, Sujata; Shipman, Jennifer M; Lumb, Kevin J; Coleman, Kevin; Dandliker, Peter J; Kariv, Ilona; Beutel, Bruce.
Afiliação
  • Kutilek VD; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA victoria.kutilek@merck.com.
  • Andrews CL; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Richards MP; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Xu Z; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Sun T; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Chen Y; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Hashke A; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Smotrov N; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Fernandez R; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Nickbarg EB; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Chamberlin C; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Sauvagnat B; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Curran PJ; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Boinay R; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Saradjian P; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Allen SJ; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Byrne N; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Elsen NL; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA Current address: AbbVie, North Chicago, IL USA.
  • Ford RE; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Hall DL; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Kornienko M; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Rickert KW; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA Current address: Medimmune, Gaithersburg, MD, USA.
  • Sharma S; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Shipman JM; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Lumb KJ; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Coleman K; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA Current address: Arvinas, New Haven, CT, USA.
  • Dandliker PJ; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Kariv I; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
  • Beutel B; Department of Pharmacology, Screening and Protein Sciences, Merck & Co, Kenilworth, NJ, USA.
J Biomol Screen ; 21(6): 608-19, 2016 Jul.
Article em En | MEDLINE | ID: mdl-26969322
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / NF-kappa B / Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Prognostic_studies Idioma: En Revista: J Biomol Screen Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / NF-kappa B / Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Prognostic_studies Idioma: En Revista: J Biomol Screen Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos