Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development.

Liu, Ying; Prentice, Kacey J; Eversley, Judith A; Hu, Cheng; Batchuluun, Battsetseg; Leavey, Katherine; Hansen, Jakob B; Wei, David W; Cox, Brian; Dai, Feihan F; Jia, Weiping; Wheeler, Michael B

Liu, Ying; Prentice, Kacey J; Eversley, Judith A; Hu, Cheng; Batchuluun, Battsetseg; Leavey, Katherine; Hansen, Jakob B; Wei, David W; Cox, Brian; Dai, Feihan F; Jia, Weiping; Wheeler, Michael B.

Afiliação

Liu Y; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Prentice KJ; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Eversley JA; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Hu C; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Batchuluun B; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Leavey K; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3360, Toronto, ON M5S 1A8, Canada.
Hansen JB; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Wei DW; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Cox B; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3360, Toronto, ON M5S 1A8, Canada.
Dai FF; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada.
Jia W; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: wpjia@sjtu.edu.cn.
Wheeler MB; Department of Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 3352, Toronto, ON M5S 1A8, Canada. Electronic address: michael.wheeler@utoronto.ca.

Cell Rep ; 14(12): 2889-900, 2016 Mar 29.

Article em En | MEDLINE | ID: mdl-26997281

Assuntos

Diabetes Mellitus Tipo 2/patologia; Furanos/sangue; Furanos/metabolismo; Estado Pré-Diabético/patologia; Propionatos/sangue; Propionatos/metabolismo; Adulto; Idoso; Animais; Diabetes Mellitus Tipo 2/metabolismo; Dieta Hiperlipídica; Modelos Animais de Doenças; Estresse do Retículo Endoplasmático/genética; Feminino; Regulação da Expressão Gênica/efeitos dos fármacos; Glucose/farmacologia; Produtos Finais de Glicação Avançada/análise; Glicólise/efeitos dos fármacos; Humanos; Insulina/metabolismo; Células Secretoras de Insulina/citologia; Células Secretoras de Insulina/metabolismo; Modelos Logísticos; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Pessoa de Meia-Idade; Obesidade/etiologia; Obesidade/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/genética; Pâncreas/metabolismo; Pâncreas/patologia; Estado Pré-Diabético/metabolismo; Espécies Reativas de Oxigênio/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Propionatos / Diabetes Mellitus Tipo 2 / Furanos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Ano de publicação: 2016 Tipo de documento: Article

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