The Pathology of Acute Liver Failure.
Adv Anat Pathol
; 23(3): 144-58, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-27058243
ABSTRACT
Acute liver failure (ALF) is a rare and severe liver disease that usually develops in 8 weeks or less in individuals without preexisting liver disease. Its chief causes worldwide are hepatitis virus infections (hepatitis A, B, and E) and drug hepatotoxicity (particularly intentional or unintentional acetaminophen toxicity). Massive hepatic necrosis is often seen in liver specimens in ALF and features marked loss of hepatocytes, variable degrees of inflammation, and a stereotypic proliferation of bile ductular structures (neocholangioles) derived from activated periportal hepatic progenitor cells. This paper reviews the liver pathology in ALF, including forms of zonal necrosis and their etiologies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Falência Hepática Aguda
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Adv Anat Pathol
Assunto da revista:
ANATOMIA
/
PATOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article