Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia.

Zhong, Mingming; Zhao, Xuwen; Li, Jinmei; Yuan, Wenjie; Yan, Gonghong; Tong, Mingming; Guo, Shuguang; Zhu, Yichao; Jiang, Yong; Liu, Yongjian; Jiang, Yu

Zhong, Mingming; Zhao, Xuwen; Li, Jinmei; Yuan, Wenjie; Yan, Gonghong; Tong, Mingming; Guo, Shuguang; Zhu, Yichao; Jiang, Yong; Liu, Yongjian; Jiang, Yu.

Afiliação

Zhong M; From the Guangdong Provincial Key Laboratory of Proteomics; Key laboratory of Transcriptomics and Proteomics of Ministry of Education of China, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, Department of Pharmacol
Zhao X; From the Guangdong Provincial Key Laboratory of Proteomics; Key laboratory of Transcriptomics and Proteomics of Ministry of Education of China, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, Department of Pharmacol
Li J; From the Guangdong Provincial Key Laboratory of Proteomics; Key laboratory of Transcriptomics and Proteomics of Ministry of Education of China, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, Department of Pharmacol
Yuan W; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 and.
Yan G; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 and.
Tong M; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 and.
Guo S; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 and.
Zhu Y; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Jiang Y; From the Guangdong Provincial Key Laboratory of Proteomics; Key laboratory of Transcriptomics and Proteomics of Ministry of Education of China, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, jiang48321@163.com.
Liu Y; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Jiang Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 and yuj5@pitt.edu.

J Biol Chem ; 291(22): 11689-97, 2016 May 27.

Article em En | MEDLINE | ID: mdl-27072130

Assuntos

Cílios/fisiologia; Regulação da Expressão Gênica; Cinesinas/metabolismo; Complexos Multiproteicos/genética; Proteínas Proto-Oncogênicas/metabolismo; Serina-Treonina Quinases TOR/genética; Proteínas Supressoras de Tumor/metabolismo; Quinases Proteína-Quinases Ativadas por AMP; Western Blotting; Células Cultivadas; Genes Supressores de Tumor; Humanos; Imunoprecipitação; Alvo Mecanístico do Complexo 1 de Rapamicina; Complexos Multiproteicos/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Proto-Oncogênicas/genética; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Proteínas Supressoras de Tumor/genética

Palavras-chave

AMP-activated kinase (AMPK); FLCN; LKB1; folliculin; mTOR complex (mTORC); mammalian target of rapamycin (mTOR); primary cilium; tumor suppressor gene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Proteínas Proto-Oncogênicas / Cílios / Cinesinas / Proteínas Supressoras de Tumor / Complexos Multiproteicos / Serina-Treonina Quinases TOR Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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