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Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome.
Völkl, Simon; Rensing-Ehl, Anne; Allgäuer, Andrea; Schreiner, Elisabeth; Lorenz, Myriam Ricarda; Rohr, Jan; Klemann, Christian; Fuchs, Ilka; Schuster, Volker; von Bueren, André O; Naumann-Bartsch, Nora; Gambineri, Eleonora; Siepermann, Kathrin; Kobbe, Robin; Nathrath, Michaela; Arkwright, Peter D; Miano, Maurizio; Stachel, Klaus-Daniel; Metzler, Markus; Schwarz, Klaus; Kremer, Anita N; Speckmann, Carsten; Ehl, Stephan; Mackensen, Andreas.
Afiliação
  • Völkl S; Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlanger, Germany;
  • Rensing-Ehl A; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany;
  • Allgäuer A; Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlanger, Germany;
  • Schreiner E; Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlanger, Germany;
  • Lorenz MR; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany;
  • Rohr J; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Ulm, Germany;
  • Klemann C; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Ulm, Germany;
  • Fuchs I; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany;
  • Schuster V; Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany;
  • von Bueren AO; Division of Pediatric Haematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany;
  • Naumann-Bartsch N; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany;
  • Gambineri E; Department of Neuroscience, Psychology, Drug Area and Child Health (NEUROFARBA), Section of Child's Health, University of Florence, Florence, Italy;
  • Siepermann K; Department of Pediatric and Adolescent Medicine, HELIOS Klinikum Krefeld, Krefeld, Germany;
  • Kobbe R; Department of Pediatrics, University Medical Centre Hamburg, Hamburg, Germany;
  • Nathrath M; Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany; Department of Pediatrics, Pediatric Oncology Center, Technische Universität München, Munich, Germany;
  • Arkwright PD; Department of Pediatric Allergy and Immunology, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom;
  • Miano M; Clinical and Experimental Haematology Unit, Giannina Gaslini Children's Hospital, Genoa, Italy; and.
  • Stachel KD; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany;
  • Metzler M; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany;
  • Schwarz K; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Ulm, Germany;
  • Kremer AN; Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlanger, Germany;
  • Speckmann C; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany; Center for Paediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, Freiburg, Germany.
  • Ehl S; Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany; Center for Paediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, Freiburg, Germany.
  • Mackensen A; Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlanger, Germany;
Blood ; 128(2): 227-38, 2016 07 14.
Article em En | MEDLINE | ID: mdl-27099149
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Transdução de Sinais / Diferenciação Celular / Linfócitos T CD8-Positivos / Síndrome Linfoproliferativa Autoimune / Serina-Treonina Quinases TOR Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Transdução de Sinais / Diferenciação Celular / Linfócitos T CD8-Positivos / Síndrome Linfoproliferativa Autoimune / Serina-Treonina Quinases TOR Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article