Evidence for extensive pleiotropy among pharmacogenes.

Oetjens, Matthew T; Bush, William S; Denny, Joshua C; Birdwell, Kelly; Kodaman, Nuri; Verma, Anurag; Dilks, Holli H; Pendergrass, Sarah A; Ritchie, Marylyn D; Crawford, Dana C

Oetjens, Matthew T; Bush, William S; Denny, Joshua C; Birdwell, Kelly; Kodaman, Nuri; Verma, Anurag; Dilks, Holli H; Pendergrass, Sarah A; Ritchie, Marylyn D; Crawford, Dana C.

Afiliação

Oetjens MT; Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA.
Bush WS; Department of Epidemiology & Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.
Denny JC; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37203, USA.
Birdwell K; Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Kodaman N; Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA.
Verma A; Center for Systems Genomics, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Dilks HH; Sarah Cannon Research Institute, Nashville, TN 37203 USA.
Pendergrass SA; Center for Systems Genomics, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Ritchie MD; Center for Systems Genomics, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Crawford DC; Department of Epidemiology & Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

Pharmacogenomics ; 17(8): 853-66, 2016 06.

Article em En | MEDLINE | ID: mdl-27249515

Assuntos

Pleiotropia Genética; Farmacogenética; Adulto; Negro ou Afro-Americano; Citocromo P-450 CYP2C19/genética; Feminino; Estudo de Associação Genômica Ampla; Genótipo; Humanos; Masculino; Pessoa de Meia-Idade; Fenótipo; Simportadores/genética

Palavras-chave

absorption, distribution, metabolism and excretion; electronic health records; genetic association study; pharmacogenomics; phenome-wide association study

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Pleiotropia Genética Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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