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Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study.
Schiopu, Elena; Chatterjee, Soumya; Hsu, Vivien; Flor, Armando; Cimbora, Daniel; Patra, Kaushik; Yao, Wenliang; Li, Jing; Streicher, Katie; McKeever, Kathleen; White, Barbara; Katz, Eliezer; Drappa, Jorn; Sweeny, Sarah; Herbst, Ronald.
Afiliação
  • Schiopu E; Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr, SPC 5370, Ann Arbor, MI, 48109, USA. eschiopu@yahoo.com.
  • Chatterjee S; Department of Rheumatologic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
  • Hsu V; Clinical Research Center, Rutgers-Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ, 08901, USA.
  • Flor A; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Cimbora D; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Patra K; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Yao W; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Li J; Department of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune, 319 North Bernardo Ave, Mountain View, CA, 94043, USA.
  • Streicher K; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • McKeever K; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • White B; Present address: Ultragenyx Pharmaceutical, 60 Leveroni Ct, Novato, CA, 94949, USA.
  • Katz E; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Drappa J; Present address: Corbus Pharmaceuticals, 100 River Ridge Dr, Norwood, MA, 02062, USA.
  • Sweeny S; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Herbst R; Departments of Research and Clinical Biologics, MedImmune, 1 MedImmune Way, Gaithersburg, MD, 20878, USA.
Arthritis Res Ther ; 18(1): 131, 2016 06 07.
Article em En | MEDLINE | ID: mdl-27267753
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Antígenos CD19 / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Antígenos CD19 / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos