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Changes in electrocorticographic beta frequency components precede spreading depolarization in patients with acute brain injury.
Hertle, Daniel N; Heer, Marina; Santos, Edgar; Schöll, Michael; Kowoll, Christina M; Dohmen, Christian; Diedler, Jennifer; Veltkamp, Roland; Graf, Rudolf; Unterberg, Andreas W; Sakowitz, Oliver W.
Afiliação
  • Hertle DN; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany. Electronic address: daniel.hertle@med.uni-heidelberg.de.
  • Heer M; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
  • Santos E; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
  • Schöll M; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
  • Kowoll CM; Department of Neurology, University of Cologne, Cologne, Germany.
  • Dohmen C; Department of Neurology, University of Cologne, Cologne, Germany; Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Diedler J; Department of Neurology, University of Heidelberg, Heidelberg, Germany.
  • Veltkamp R; Department of Neurology, University of Heidelberg, Heidelberg, Germany.
  • Graf R; Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Unterberg AW; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
  • Sakowitz OW; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
Clin Neurophysiol ; 127(7): 2661-7, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27291885
OBJECTIVE: Spreading depolarization (SD) occurs after traumatic brain injury, subarachnoid hemorrhage, malignant hemispheric stroke and intracranial hemorrhage. SD has been associated with secondary brain injury, which can be reduced by ketamine. In this present study frequency bands of electrocorticographic (ECoG) recordings were investigated with regards to SDs. METHODS: A total of 43 patients after acute brain injury were included in this retrospective and explorative study. Relative delta 0.5-4Hz, theta 4-8Hz, alpha 8-13Hz and beta 13-40Hz bands were analyzed with regards to SD occurrence and analgesic and sedative administration. Higher frequencies, including gamma 40-70Hz, fast gamma 70-100Hz and high frequency oscillations 100-200Hz were analyzed in a subset of patients with a sampling rate of up to 400Hz. RESULTS: A close association of relative beta frequency and SD was found. Relative beta frequency was suppressed up to two hours prior to SD when compared to hours with no SD. This finding was partially explained by administration of ketamine. Even after removal of all patient data during administration of ketamine, SDs occurred predominantly during times with low relative beta frequency in a patient-independent analysis. CONCLUSION: Suppression of beta frequency by ketamine or without ketamine is associated with low SD counts. SIGNIFICANCE: Alteration of beta frequency might help to predict occurrence of SDs in acutely brain injured patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo beta / Lesões Encefálicas Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo beta / Lesões Encefálicas Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article