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The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women.
Salimi, Saeedeh; Hajizadeh, Azam; Yaghmaei, Minoo; Rezaie, Sodabeh; Shahrakypour, Mahnaz; Teimoori, Batool; Parache, Mahboube; Naghavi, Anoosh; Mokhtari, Mojgan.
Afiliação
  • Salimi S; Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Hajizadeh A; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Yaghmaei M; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Rezaie S; Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshty University of Medical Sciences, Tehran, Iran. yaghmaeim@yahoo.com.
  • Shahrakypour M; Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Teimoori B; Department of Biostatistics and Epidemiology, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Parache M; Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Naghavi A; Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Mokhtari M; Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Tumour Biol ; 37(9): 12497-12502, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27337955
Uterine leiomyoma (UL) is a monoclonal tumor which arises from uninhibited proliferation of a single myometrial cell; therefore, the imbalance in cell cycle regulation could be a key event in its development. In the present study, we aimed to assess the association of p21 gene polymorphisms and UL. Genomic DNA was extracted from blood samples of 154 women with UL and 197 age-, BMI-, and ethnically matched controls. p21 C98A (rs1801270) and C70T (rs1059234) polymorphism genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The CA genotype of p21 C98A polymorphism was significantly higher in UL women (28 %) compared to the controls (18 %), and the UL risk was 1.8-fold greater in women with CA genotype compared to CC genotype before and after adjusting for age, BMI, and ethnicity (OR, 1.8 [95 % CI, 1.1 to 3]; P = 0.02). There was no association between the AA genotype of p21 C98A polymorphism and UL. Moreover, the frequency of p21 98A allele was significantly higher in the UL women compared to controls (17 vs. 12 %, p = 0.04). The p21 C70T polymorphism did not correlate with UL before and after adjusting for age, BMI, and ethnicity. There was no difference in haplotype frequency of p21 C70T and C98A polymorphisms between UL patients and the controls. CA genotype of p21 C98A polymorphism may be a risk factor for UL susceptibility; however, p21 C70T polymorphism did not associate with UL.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Neoplasias Uterinas / Predisposição Genética para Doença / Inibidor de Quinase Dependente de Ciclina p21 / Leiomioma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Tumour Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Neoplasias Uterinas / Predisposição Genética para Doença / Inibidor de Quinase Dependente de Ciclina p21 / Leiomioma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Tumour Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã