Development of the adaptive NK cell response to human cytomegalovirus in the context of aging.
Mech Ageing Dev
; 158: 23-6, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27349430
ABSTRACT
Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence and an increase mortality rate in elderly people. Such long-term detrimental effects of the viral infection presumably result from an inefficient immune control of the pathogen, depending on the quality and evolution of the individual host-pathogen relationship. Together with antigen-specific T lymphocytes, NK cells play an important role in anti-viral immune defense. HCMV promotes in some individuals the differentiation and persistent steady state expansion of an NK cell subset bearing the CD94/NKG2C activating receptor. The relationship between this adaptive NK cell response to HCMV and aging is overviewed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Células Matadoras Naturais
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Infecções por Citomegalovirus
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Citomegalovirus
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Subfamília D de Receptores Semelhantes a Lectina de Células NK
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Imunidade Celular
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2016
Tipo de documento:
Article