New MAPS for misfolded proteins.

Volkmar, Norbert; Fenech, Emma; Christianson, John C

Volkmar, Norbert; Fenech, Emma; Christianson, John C.

Afiliação

Volkmar N; Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.
Fenech E; Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.
Christianson JC; Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.

Nat Cell Biol ; 18(7): 724-6, 2016 Jun 28.

Article em En | MEDLINE | ID: mdl-27350445

ABSTRACT

ABSTRACT

Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.

Assuntos

Citoplasma/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Dobramento de Proteína; Ubiquitina-Proteína Ligases/metabolismo; Animais; Homeostase/fisiologia; Humanos; Transporte Proteico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dobramento de Proteína / Citoplasma / Ubiquitina-Proteína Ligases / Complexo de Endopeptidases do Proteassoma Limite: Animals / Humans Idioma: En Revista: Nat Cell Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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