Drug-specific CD4<sup>+</sup> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome.

Ye, Y-M; Hur, G-Y; Kim, S-H; Ban, G-Y; Jee, Y-K; Naisbitt, D J; Park, H-S; Kim, S-H

Drug-specific CD4⁺ T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome.

Ye, Y-M; Hur, G-Y; Kim, S-H; Ban, G-Y; Jee, Y-K; Naisbitt, D J; Park, H-S; Kim, S-H.

Afiliação

Ye YM; Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
Hur GY; Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea.
Kim SH; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Ban GY; Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
Jee YK; Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea.
Naisbitt DJ; MRC Centre for Drug Safety Science, Department of Clinical and Molecular Pharmacology, The University of Liverpool, Liverpool, U.K.
Park HS; Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
Kim SH; Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.

Br J Dermatol ; 176(2): 378-386, 2017 Feb.

Article em En | MEDLINE | ID: mdl-27373553

Assuntos

Antituberculosos/efeitos adversos; Linfócitos T CD4-Positivos/imunologia; Síndrome de Hipersensibilidade a Medicamentos/imunologia; Exantema/induzido quimicamente; Imunidade Celular/imunologia; Adulto; Antituberculosos/imunologia; Exantema/imunologia; Feminino; Antígenos HLA/efeitos dos fármacos; Antígenos HLA/imunologia; Humanos; Isoniazida/efeitos adversos; Isoniazida/imunologia; Masculino; Pessoa de Meia-Idade; Rifampina/efeitos adversos; Rifampina/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Exantema / Síndrome de Hipersensibilidade a Medicamentos / Imunidade Celular / Antituberculosos Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Dermatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Coréia do Sul

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