Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E-deficient mice and cells.

Ryu, Hye-Myung; Kim, You-Jin; Oh, Eun-Joo; Oh, Se-Hyun; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Park, Sun-Hee; Kim, Yong-Lim

Ryu, Hye-Myung; Kim, You-Jin; Oh, Eun-Joo; Oh, Se-Hyun; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Park, Sun-Hee; Kim, Yong-Lim.

Afiliação

Ryu HM; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim YJ; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Oh EJ; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Oh SH; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Korea.
Choi JY; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Cho JH; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim CD; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Park SH; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim YL; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Korea.

J Cell Mol Med ; 20(11): 2160-2172, 2016 11.

Article em En | MEDLINE | ID: mdl-27396856

Assuntos

Apolipoproteínas E/deficiência; Aterosclerose/patologia; Colesterol/metabolismo; Hipoxantina/farmacologia; Acetilcisteína/farmacologia; Alopurinol/farmacologia; Animais; Apolipoproteínas E/metabolismo; Aterosclerose/sangue; Colesterol/sangue; Regulação para Baixo/efeitos dos fármacos; Regulação para Baixo/genética; Células Hep G2; Humanos; Peróxido de Hidrogênio/toxicidade; Hipercolesterolemia/patologia; Lipogênese/efeitos dos fármacos; Lipogênese/genética; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Modelos Biológicos; Placa Aterosclerótica/sangue; Placa Aterosclerótica/metabolismo; Placa Aterosclerótica/patologia; Regulação para Cima/efeitos dos fármacos

Palavras-chave

APOE; ROS; atherosclerosis; cholesterol; hypoxanthine

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Colesterol / Hipoxantina / Aterosclerose Limite: Animals / Humans / Male Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google