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Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.
Akman, Gokhan; Desai, Radha; Bailey, Laura J; Yasukawa, Takehiro; Dalla Rosa, Ilaria; Durigon, Romina; Holmes, J Bradley; Moss, Chloe F; Mennuni, Mara; Houlden, Henry; Crouch, Robert J; Hanna, Michael G; Pitceathly, Robert D S; Spinazzola, Antonella; Holt, Ian J.
Afiliação
  • Akman G; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Desai R; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Bailey LJ; Medical Research Council Mitochondrial Biology Unit, Cambridge CB1 9SY, United Kingdom;
  • Yasukawa T; Medical Research Council Mitochondrial Biology Unit, Cambridge CB1 9SY, United Kingdom;
  • Dalla Rosa I; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Durigon R; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Holmes JB; Medical Research Council Mitochondrial Biology Unit, Cambridge CB1 9SY, United Kingdom; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892;
  • Moss CF; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Mennuni M; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom;
  • Houlden H; Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, United Kingdom;
  • Crouch RJ; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892;
  • Hanna MG; Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, United Kingdom;
  • Pitceathly RD; Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, United Kingdom; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kin
  • Spinazzola A; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom; ian.holt@headoffice.mrc.ac.uk Antonella.Spinazzola@crick.ac.uk.
  • Holt IJ; Medical Research Council, Mill Hill Laboratory, London NW7 1AA, United Kingdom; ian.holt@headoffice.mrc.ac.uk Antonella.Spinazzola@crick.ac.uk.
Proc Natl Acad Sci U S A ; 113(30): E4276-85, 2016 07 26.
Article em En | MEDLINE | ID: mdl-27402764
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Ribonuclease H / Mitocôndrias / Mutação Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Ribonuclease H / Mitocôndrias / Mutação Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article