Experimental murine chromomycosis mimicking chronic progressive human disease.
Am J Trop Med Hyg
; 40(6): 651-8, 1989 Jun.
Article
em En
| MEDLINE
| ID: mdl-2742041
ABSTRACT
Congenitally athymic (nu/nu) mice, mice defective in NK cell and macrophage function (bg/bg), and normal BALB/c mice were inoculated sc with 10 conidia of Fonsecaea pedrosoi (FP). In immunologically intact and immunodeficient mice, a local infection developed approximately 2 weeks post-inoculation and enlarged over 1-2 weeks. In bg/bg and normal nu/+ mice, lesions resolved within 5-6 weeks. However, nu/nu mice continued to have enlarging sc lesions during greater than 4-6 months of observation. These eventually metastasized. Lesions contained few hyphal elements and massive numbers of sclerotic bodies. Five weeks after inoculation, 10 conidia forming units/gm of tissue were recovered from lesions. Delayed type hypersensitivity and serum antibody to FP antigens were demonstrated. Adoptive transfer of lymphocytes from nu/+ mice was followed in 2 months by the resolution of the lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromoblastomicose
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1989
Tipo de documento:
Article