Structure-activity relationships and action mechanisms of collagen-like antimicrobial peptides.
Biopolymers
; 108(1)2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27487034
ABSTRACT
An antimicrobial triple-helical peptide, R3, was previously obtained from a collagen-like combinatorial peptide library. In this research, based on structure-activity relationship studies of R3, a more potent peptide, RR4, with increased positive net charge and charge density relative to R3, was developed. RR4 exhibited antimicrobial activity against both Gram-negative and Gram-positive bacterial strains, including multidrug-resistant strains. Its action could be attributed to entry into cells and interactions with intercellular molecules such as DNA/RNA that inhibited cell division rather than increasing bacterial membrane permeability. Furthermore, RR4 exhibited remarkable stability in serum and low cytotoxicity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colágeno
/
Peptídeos Catiônicos Antimicrobianos
Limite:
Humans
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão