Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review.
J Am Acad Dermatol
; 75(5): 1038-1044, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27522613
ABSTRACT
BACKGROUND:
Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardized methods for capturing long-term control of AD.OBJECTIVE:
We sought to identify how long-term control has been captured in published randomized controlled trials (RCTs). Results will initiate consensus discussions on how best to measure long-term control in the core outcome set for AD.METHODS:
We conducted a systematic review of RCTs of AD treatments published between 2000 and 2013, with a follow-up period of 3 months or longer, at least 1 outcome measure recorded at 3 or more time points, full article available, and published in English.RESULTS:
In all, 101 of 353 RCTs were eligible. Methods to capture long-term control included repeated measurement of AD outcomes (92 RCTs; 91%), use of AD medication (29 RCTs; 28.7%), and AD flares/remissions (26 RCTs; 25.7%). Repeated measurements of AD outcomes were typically collected 3 to 5 times during a trial, but analysis methods often failed to make best use of the data. Time to first flare was most commonly used for trials including flare data (21/52). Medication use was recorded based on quantity, potency, and frequency of application.LIMITATIONS:
We included RCT data only.CONCLUSION:
This review illustrates the difficulties in measuring long-term control, and points to the need for improved harmonization of outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Dermatite Atópica
/
Fármacos Dermatológicos
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França