Adenylate degradation products release from the human myocardium during open heart surgery.
Clin Chim Acta
; 182(1): 63-73, 1989 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-2752581
ABSTRACT
Purine degradation products were determined in the human heart coronary sinus effluent collected from patients undergoing cardiac surgery, during infusion of a cardioplegic solution. At the onset of cardiopulmonary bypass the mean concentrations of adenosine, inosine and hypoxanthine were 0.1, 0.5 and 0.3 mumol/l, respectively. Ischemic arrest leads to a progressive increase of the respective levels to 1.4 17.8 and 9.6 mumol/l after 60-80 min of ischemia. Xanthine concentration was undetectable (less than 0.2 mumol/l) throughout. A substantial urate release (20 mumol/l) was observed which decreased with the duration of ischemia. Xanthine oxidoreductase activity in human myocardium was found to be below the detection limit (0.1 mU/g wet weight). Thus, urate release represented wash out of urate which had accumulated in the tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Miocárdio
Limite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Polônia