Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.

Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J

Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J.

Afiliação

Rabbani N; AGE-omics and Systems Biology Research Group, Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, U.K.
Xue M; Glyoxalase Research Group, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.
Thornalley PJ; AGE-omics and Systems Biology Research Group, Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, U.K. Glyoxalase Research Group, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K. P.J.Thornalley@warwick.ac.uk.

Clin Sci (Lond) ; 130(19): 1677-96, 2016 10 01.

Article em En | MEDLINE | ID: mdl-27555612

Assuntos

Envelhecimento/fisiologia; Tratamento Farmacológico; Lactoilglutationa Liase/uso terapêutico; Aldeído Pirúvico/toxicidade; Envelhecimento/efeitos dos fármacos; Envelhecimento/genética; Animais; Doença/genética; Humanos; Lactoilglutationa Liase/genética; Lactoilglutationa Liase/metabolismo; Estresse Fisiológico/efeitos dos fármacos

Palavras-chave

cardiovascular disease; diabetes; glycation; glyoxalase; methylglyoxal; multidrug resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aldeído Pirúvico / Envelhecimento / Tratamento Farmacológico / Lactoilglutationa Liase Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Clin Sci (Lond) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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