Risk factors for neonatal nosocomial enteric infection and the effect of intervention with BIFICO.

ABSTRACT

OBJECTIVE: This study aims to investigate the risk factors for neonatal nosocomial enteric infection (NNEI) and the effect of intervention with BIFICO. PATIENTS AND METHODS: Between May 2013 and June 2015, 215 neonates admitted to our institution were randomly divided into the study group and the control group, 47 for each group. Patients in the study group were treated for primary diseases combined with the oral admission of BIFICO, whereas patients in the control group were treated for primary disease alone. Statistical analysis was performed to obtain the occurrence of enteric infection and univariate, as well as multivariate analysis of clinical data, were performed to investigate the underlying risk factors. RESULTS: Univariate and multivariate analysis of variance showed that gestational age, birth weight, length of hospital stay, invasive procedures and underlying diseases were risk factors affecting NNEI. The occurrence of NNEI in the study group was significantly lower than that in the control group [17.02% (8/47) vs. 29.79% (14/47), X2 = 19.394, p = 0.004]. CONCLUSIONS: Preterm infant, low-birth-weight infant, length of hospital stay, invasive procedures and comorbidity are independent risk factors for NNEI. Prophylactic therapy with BIFICO can effectively decrease the occurrence of infections and can be widely used in clinical practice.