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Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze, Jörg O; Saladino, Giorgio; Busschots, Katrien; Neimanis, Sonja; Süß, Evelyn; Odadzic, Dalibor; Zeuzem, Stefan; Hindie, Valerie; Herbrand, Amanda K; Lisa, María-Natalia; Alzari, Pedro M; Gervasio, Francesco L; Biondi, Ricardo M.
Afiliação
  • Schulze JO; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Saladino G; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
  • Busschots K; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Neimanis S; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Süß E; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Odadzic D; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Zeuzem S; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Hindie V; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Herbrand AK; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Lisa MN; Structural Biochemistry Unit, Pasteur Institute, Rue du Docteur Roux 25, 75724 Paris, France.
  • Alzari PM; Structural Biochemistry Unit, Pasteur Institute, Rue du Docteur Roux 25, 75724 Paris, France.
  • Gervasio FL; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Research Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: f.l.gervasio@ucl.ac.uk.
  • Biondi RM; Research Group PhosphoSites, Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address: biondi@med.uni-frankfurt.de.
Cell Chem Biol ; 23(10): 1193-1205, 2016 Oct 20.
Article em En | MEDLINE | ID: mdl-27693059
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Trifosfato de Adenosina / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Regulação Alostérica / Indazóis Limite: Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Trifosfato de Adenosina / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Regulação Alostérica / Indazóis Limite: Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha