The neurobiology of self-processing in abused depressed adolescents.
Dev Psychopathol
; 29(3): 1057-1073, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-27760585
ABSTRACT
Maltreatment is associated with chronic depression, high negative self-attributions, and lifetime psychopathology. Adolescence is a sensitive period for the formation of self-concept. Identifying neurobiomarkers of self-processing in depressed adolescents with and without maltreatment may parse the effects of trauma and depression on self-development and chronic psychopathology. Depressed adolescents (n = 86) maltreated due to omission (DO, n = 13) or commission (DCM, n = 28) or without maltreatment (DC, n = 45), and HCs (HC, n = 37) appraised positive and negative self-descriptors in the scanner. DCM and DO showed hypoactivity in the dorsal anterior cingulate cortex (dACC) while processing positive versus negative self-descriptors compared to DC youth, who in turn showed reduced dACC recruitment versus HC. HC youth showed the highest activation in the dACC and striatum during positive self-descriptors; these regions showed a linear decline in activity across DC, DO, and DCM. Low dACC activity to positive versus negative self-descriptors was linked to inadequate coregulation of children's emotions by parents. Negative self-cognitions prevalent in DCM and DO adolescents may be perpetuated by activity in the dACC and striatum. Reduced activation of the dACC and striatum for positive self-descriptors, coupled with enhanced activity for negative self-descriptors, may heighten the risk for persistent depression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoimagem
/
Maus-Tratos Infantis
/
Neostriado
/
Depressão
/
Giro do Cíngulo
Limite:
Adolescent
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Female
/
Humans
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Male
Idioma:
En
Revista:
Dev Psychopathol
Assunto da revista:
PSICOLOGIA
/
PSIQUIATRIA
Ano de publicação:
2017
Tipo de documento:
Article